Searching for short sequences using BLAST can produce an overwhelming amount of irrelevant results. Why? The BLAST algorithm has heuristic limitations that render it ineffective and cumbersome for short sequence searches. This white paper gives you detailed insight on BLAST shortcomings and more advanced, alternative approaches that vastly reduce short sequence search times and deliver accurate, definitive results in minutes. If you are struggling with short-sequence searches, this paper is a must-read.
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