Drug Rescue

More and more, our pharma customers are recognizing the value of using genomics to rescue drugs in trials or post-market. There are many ways for drugs to fail, and the industry’s desire is to fail them early and often – unless there is a way to keep them alive.

Take the example of a drug already in the market that is showing a small population of patients with adverse events. The FDA is monitoring the reports. Patients taking the drug are at risk, the market is retracting, and the drug itself may need to be pulled.

Drug Rescue

Drug Rescue Application

GenomeQuest provides a solution. Using our Whole Genome Analysis suite, pharma customers have sequenced the exomes of cohorts of patients who are either experiencing adverse events or who are strong responders with no off-label side effects. Then, these exomes are pushed through our Multi-Genome Analysis application, and the alleles that are predictive of patients’ inclusion in one of the two groups are identified.

Such genotyping enables pharma to determine whether they want to proactively pull the drug, or to develop a companion diagnostic that can keep the drug on the market for specific genotypes.

GenomeQuest Applications

All GenomeQuest science applications are delivered in an easy-to-use, integrated environment. They package all bioinformatics details – including read and reference data, scientific algorithms, all third party integration, all parameters, and the compute environment – into a simple form-based interface. Users query results using an interactive sequence browser. All data, parameters, and results can be shared with colleagues and teams using the GenomeQuest collaborative environment.

GenomeQuest applications are built to scale to thousands of samples, each with billions of reads. They support all popular sequencing machines (including Illumina, SOLiD, 454, and PacBio) and all common formats (including FASTQ, FASTA, SAM/BAM, VCF, SVA, and others).