Multi-Genome Analysis

GenomeQuest’s Multi-Genome Analysis highlights the underlying power of the GenomeQuest Engine by allowing you to compare the genomes of arbitrarily large populations. The application’s inputs are genomes that have already been analyzed using GenomeQuest’s Whole Genome Analysis, and includes the following features:

MGA

Multi-Genome Analysis Interface

  1. Analysis of allelic differences between organisms. GenomeQuest allows you to compare the genomes of two, ten, or 10,000 organisms to determine which alleles they have in common and which are different.
  2. Analysis of allelic frequencies across populations. By combining genomes into population groups, the same capability allows large-scale population studies, allowing you to find alleles which are over- or under-represented in one population versus another.
  3. Trio studies. Mother/father/offspring analysis is innately supported in this application.
  4. Arbitrary reference genomes. Just as the Whole Genome Analysis application allows you to process genomes from any reference genome, Multi-Genome Analysis allows the same.
  5. Availability of the 1,000 Genomes data. The 1,000 Genomes data is already available as an overlay for your proprietary data.
  6. Support for whole genome, exome, and targeted resequencing. It runs on complete genomes or any smaller selection.
  7. Back to the evidence. Every allele shared or not shared by a given genome or population can be examined, down to the underlying reads that drove the allele call.

GenomeQuest Applications

All GenomeQuest science applications are delivered in an easy-to-use, integrated environment. They package all bioinformatics details – including read and reference data, scientific algorithms, all third party integration, all parameters, and the compute environment – into a simple form-based interface. Users query results using an interactive sequence browser. All data, parameters, and results can be shared with colleagues and teams using the GenomeQuest collaborative environment.

GenomeQuest applications are built to scale to thousands of samples, each with billions of reads. They support all popular sequencing machines (including Illumina, SOLiD, 454, and PacBio) and all common formats (including FASTQ, FASTA, SAM/BAM, VCF, SVA, and others).